American will resume service from Philadelphia International Airport (PHL) to Des Moines International Airport (DSM) in Des Moines, IA and Eppley Airfield (OMA) in Omaha, NE on June 5th, 2025

The flights to both Des Moines and Omaha will be operated twice daily by American Eagle’s PSA affiliate on CRJ-900 aircraft with 12 first class, 24 Main Cabin Extra and 40 Main Cabin seats.

• AA 5566 departs PHL at 10:55 am and arrives in DSM at 1:00 pm.

• AA 5478 departs PHL at 6:30 pm and arrives in DSM at 8:32 pm.

• AA 5479 departs DSM at 6:00 am and arrives in PHL at 9:40 am.

• AA 5082 departs DSM at 2:00 pm and arrives in PHL at 5:40 pm.

• AA 5103 departs PHL at 11:00 am and arrives in OMA at 1:00 pm.

• AA 5545 departs PHL at 6:30 pm and arrives in OMA at 8:44 pm.

• AA 5074 departs OMA at 6:00 am and arrives in PHL at 9:50 am.

• AA 5655 departs OMA at 1:40 pm and arrives in PHL at 5:30 pm.

Logical resumptions for AA, especially for connections to American’s vast European service from Philly. Recently, the airline launched daily flights from PHL to Northwest Arkansas International Airport (XNA) adding to the list of thinner routes for the carrier from Philly to the middle of the country. If the carrier continues this trend cities like Oklahoma City, OK; Tulsa, OK; or Little Rock, AR may be in PHL’s future.